Fig. 1.

BDNF enhances high K⁺-evoked GABA release from cultured hippocampal neurons. After long-term treatment with 50 ng/ml BDNF from 1 to 7–11 d in vitro, cultures were stimulated by K⁺ depolarization (50 mm, 1 min), and the amount of released glutamate (A) and GABA (B) was quantified by HPLC. BDNF enhances high K⁺-evoked release of GABA but not of glutamate. Data are means ± SEM of seven wells. *p < 0.05 versus control, Student's t test.