Immunocytochemical determination of NK1 receptor expression in the DRN and LHb of guinea pig and rhesus monkey brain. The DRN of the guinea pig and cynomolgus monkey (a, b), in contrast to the rat (c), shows little NK1 receptor immunoreactivity, with only scattered nonmonoaminergic cells labeled (arrowhead, b). NK1 receptor immunoreactivity is prominent in the LHb of the guinea pig (d) and primate (e) but not in the rat (f). Scale bars:a–c, 200 μm; d–f, 250 μm.MHb, Medial habenula; IV, fourth ventricle; mlf, medial longitudinal fasiculus.