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. 2002 Sep 1;22(17):7509–7517. doi: 10.1523/JNEUROSCI.22-17-07509.2002

Fig. 3.

Fig. 3.

Effects of 5-HT (10 μm) and α-methyl-5-HT (10 μm) on EPSCs in DLSN neurons. ACSF contained bicuculline (15 μm) and CGP 55845 (4 μm) to block IPSPs in all experiments. Data points are averages of six responses. Periods of drug application are indicated byhorizontal bars. Bottom traces inA and B are sample records of neuron responses at the times indicated by the correspondingletters on the graph. Open triangles indicate the time of fimbria stimulation.A, Facilitation of the EPSC induced by 5-HT (10 μm) in a DLSN neuron voltage-clamped at –70 mV. Thedotted line indicates predrug membrane current (also inB). B, Effects of α-methyl-5-HT (10 μm) on the EPSC. Holding membrane potential was –70 mV.C, Time course of the effects of 5-HT (3 μm) on the EPSC and the membrane conductance. The membrane conductance was monitored via the change in inward currents induced by hyperpolarizing voltage commands (10 mV for 80 msec). The facilitation of the EPSC by 5-HT was preceded by the membrane conductance change.