Fig. 8.

Blockade of kainate-induced dystonia by coadministration of NBQX. Mice were microinjected with the glutamate receptor antagonist NBQX alone and with 100 μg/ml kainic acid. Disability scores were recorded every 10 min for 2 hr; total disability score represents the sum of the scores for the entire 2 hr observation period. Data represent means ± SEM (n = 5 per group). **p < 0.01, indicates a significant reduction in dystonia after NBQX coadministration with kainic acid compared with kainic acid alone (one-factor ANOVA; Scheffe'spost hoc analysis). NBQX plus kainic acid coadministration was not significantly different from administration of NBQX alone.