The 6-month-old APPSw mice have increased levels of phosphorylated Bad in hippocampal neurons. Nontransgenic mice have low levels of Bad phosphorylated at Ser112 in CA1 (A) and dentate gyrus (C) neurons, but levels of phospho-Bad are increased in CA1 (B) and the dentate gyrus (D) of APPSw mice. Scale bars:B (for A, B), D (forC, D), 10 μm.