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. 2002 Sep 1;22(17):7380–7388. doi: 10.1523/JNEUROSCI.22-17-07380.2002

Fig. 5.

Fig. 5.

RT-PCR from the hippocampus and cerebellum of APPSw and nontransgenic mice. A, The 6-month-old mice that contain and express the human APPSwtransgene (lanes 2, 4, 6) have increased levels of transthyretin (TTR) and insulin-like growth factor-2 (IGF-2) in the hippocampus when compared with nontransgenic littermates (lanes 1, 3, 5). In the cerebellum the increase in TTR expression is reduced and the increase in IGF-2 is eliminated when comparing APPSw mice (lanes 2, 4, 6) with nontransgenic littermates (lanes 1, 3, 5). B, At 12 months the increased expression of TTR and IGF-2 in the hippocampus of APPSw mice remains (lanes 2, 4) when compared with nontransgenic controls (lanes 1, 3).