Fig. 7.
Hypothetical schema showing integration of neuroprotective Akt and Erk1/2 pathways in APPSw mice. All differentially expressed genes or proteins (grayed text) that have been shown previously to have a role in the inhibition or activation of apoptosis or are involved in Aβ sequestration are shown. Also indicated is the increased (↑) or decreased (↓) gene expression or protein activation in APPSw mice. Between proteins the black arrows represent the activation of one protein by another, and the bars represent inhibition. AC, Adenylate cyclase; GHR, growth hormone receptor;IRS-1, insulin receptor substrate 1;MKK4, MAPK kinase 4; NFT, neurofibrillary tangles; p-IGF-1Rβ, tyrosine-phosphorylated IGF-1 receptor β; p90RSK, 90 kDa ribosomal S6 kinases;PAC1R, type I PACAP receptor;PKA, protein kinase A; PRLR, prolactin receptor.