Fig. 9.

Astrocytosis in the spinal cord and denervation atrophy in skeletal muscle from mice of the human P301S tau line.A, B, The ventral gray matter of the spinal cord (level L2–L3) from a 6-month-old control mouse (A) and a transgenic mouse (B) of the same age was stained with an anti-glial fibrillary acidic protein antibody. Note the weak immunoreactivity in A and the much stronger staining inB, as reflected in a large number of immunopositive astrocytic cell bodies and coarse processes. C, Hindlimb skeletal muscle from a transgenic mouse was stained with toluidine blue. Groups of atrophic, angulated muscle fibers are indicated byarrows. Scale bars: A, 50 μm (forA, B); C, 60 μm.