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. 2002 Nov 1;22(21):9298–9304. doi: 10.1523/JNEUROSCI.22-21-09298.2002

Fig. 4.

Fig. 4.

Quantitative analysis of amyloid production and neurodegeneration. A, Determination of percentage area of the neuropil occupied by Aβ immunoreactive deposits in the frontal cortex and hippocampus. B, Determination of Aβ levels in the hippocampus by ELISA in 10- and 18-month-old mice. *p < 0.05, different by two-tailed unpairedt test when compared with hAPP tg mice.C, Densitometrical analysis of GFAP immunoreactivity in the hippocampus using the Quantimet 570C in 10- and 18-month-old mice. *p < 0.05 different from non-tg control by one-way ANOVA post hoc Dunnet's test. D, Levels of MAP2-IR in the outer molecular layer of the dentate gyrus in 10- and 18-month-old mice. *p < 0.05, different by one-way ANOVA post hoc Dunnet's test.