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Application of the D4agonist PD168077 reversibly reduced GABAA receptor currents in PFC pyramidal neurons. A, Photomicrograph of an acutely isolated PFC pyramidal neuron. B, Currenttraces recorded from the neuron shown inA. The D4 agonist PD168077 (PD; 20 μm) reduced GABA-evoked (50 μm) currents in the cell. C, Plot of peak GABAA current as a function of time and agonist application in a sample of dissociated PFC pyramidal neurons (n= 45).
