Table 1.
Neuronal firing rates and correlation in the pallidum
| Normal | MPTP1-a | DRT-off1-b | DRT-on1-c | ||
|---|---|---|---|---|---|
| A. Firing rates (spikes/sec), | GPe | 57.1 ± 2.1 (n = 96) | 45.4 ± 1.7 (n = 92)* | 30.3 ± 1.9 (n = 89)* | 80.3 ± 3.8 (n = 51)*,** |
| mean ± SEM1-d | GPi | 62.9 ± 3.3 (n = 22) | 75.3 ± 4.5 (n = 37) | 69.5 ± 5.9 (n = 17) | 29.1 ± 4.7 (n = 30)*,** |
| B. Percentage of correlated | GPall-GPall1-f | 16.7% (100/599) | 46.9% (399/851)* | 71.4% (359/503)* | 25.0% (94/376)** |
| neuronal pairs1-e | GPe-GPe | 26.3% (26/99) | 41.9% (26/62) | 78.8% (93/118)* | 32.6% (14/43)** |
| GPi-GPi | 20.0% (9/45) | 82.1% (55/67)* | 80.0% (8/10)* | 57.1% (12/21) | |
| C. Percentage of oscillatory out | GPall-GPall1-f | 4.0% (4/100) | 67.7% (270/399)* | 43.7% (157/359)* | 42.6% (40/94)* |
| of all non-flat correlograms1-e | GPe-GPe | 15.4% (4/26) | 38.5% (10/26) | 45.2% (42/93) | 35.7% (5/14) |
| GPi-GPi | 0% (0/9) | 94.5% (52/55)* | 87.5% (7/8)* | 83.3% (10/12)* |
F1-a
MPTP corresponds to MPTP-treatedl-DOPA-naive parkinsonian monkey.
F1-b
DRT-off corresponds to off periods (before morning dose) of MPTP monkey undergoing daily DRT.
F1-c
DRT-on corresponds to on periods of MPTP monkey after DRT.
F1-d
Comparisons were done using Student'st test. All states were compared with the normal state (*p < 0.001). DRT-on was compared with DRT-off as well (**p < 0.001).
F1-e
Comparisons were done using χ2 test. All states were compared with the normal state (*p < 0.001). DRT-on was compared with DRT-off as well (**p < 0.001).
F1-f
GPall-GPall—all combinations of GPe, GPi, and GP neuronal pairs.