Fig. 1.

A, Histogram showing the number of SNpc neurons (mean ± SE) of WT, IL-1R(−/−), and IL-6(−/−) mice. Total counts of SNpc neurons stained with neutral red are shown in black, and TH-IR counts are shown inwhite. IL-6(−/−) mice had significantly less (8.5%) TH-IR stained cells than WT mice. No significant difference was seen in any other groups. B, Histograms showing the terminal tree size of SNpc neurons in WT, IL-1R(−/−), and IL-6(−/−) mice (mean ± SE). Terminal arbor size was significantly increased (29 and 25%) in IL-1R(−/−) and IL-6(−/−) mice, respectively.C shows the density of astrocytes in which a significant increase in astrocytes (34%) in the IL-1R(−/−) mice compared with WT. D, Density of microglia. No significant difference was seen in the density of microglia in any of the genotypes. *p < 0.05.