Fig. 2.

This figure compares the terminal tree sizes as well as microglia and astrocyte density of WT, IL-1R(−/−), and IL-6(−/−) mice before (black bars) and after (white bars) long-term haloperidol treatment. Mean ± SE. A, Haloperidol caused a significant increase (35%) in terminal tree size in WT animals but had no effect in the knock-out groups. B, A significant increase in the density of GFAP-IR astrocytes occurred in the WT and IL-6(−/−) mice after treatment (46 and 43%, respectively). C, A significant increase in GSI-B₄-IR microglia density followed haloperidol treatment of WT and IL-6(−/−) mice (137 and 43%, respectively). Haloperidol had no effect on the density of either microglia or astrocytes in IL-1R(−/−) mice. *p < 0.05, significant differences from untreated animals.