Fig. 3.

This figure illustrates the extent of microglia and astrocyte proliferation in WT, IL-1R(−/−), and IL-6(−/−) mice 4 d (black dotted line) and 2 months (black solid line) after varying SNpc lesion sizes.A–C show the density of GFAP-IR astrocytes in WT, IL-1R(−/−), and IL-6(−/−) after lesion. Note the linear increase in microglia density as lesion size increases in the WT and IL-6(−/−) mice. D–F show GSI-B₄-IR microglia density in lesioned WT, IL-1R(−/−), and IL-6(−/−) mice, respectively. A steady increase in microglial density was evident in WT and IL-6(−/−) mice as lesion size increased. The solid gray linerepresents cell density in untreated animals, and the dotted gray line shows the effects of haloperidol on cell density.