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. 2002 Sep 15;22(18):8042–8051. doi: 10.1523/JNEUROSCI.22-18-08042.2002

Fig. 6.

Fig. 6.

Plot of fEPSP slope measurements expressed as percentage change from baseline as recorded before and after HFS (arrow). Data have been averaged in 2 min bins for individual animals and then averaged across animals for each group and expressed as mean ± SEM. LTP was induced in vehicle-treated animals (○) but blocked in MK-801-treated animals (●).Inset waveforms are averages of 30 responses taken at the times indicated before and after HFS. Calibration: 3 mV, 5 msec. Administration of the NMDA receptor antagonist MK-801 has no effect in cells expressing GluR1(Q)flip during late postnatal development.Graph illustrates quantification of GluR1(Q)flip-expressing cells from animals treated with saline or MK-801: number of branch-points and branch tips (A); number of primary dendrites (B); total arbor and longest dendritic path per cell (C); and soma area (D). MK-801 or saline was administered subcutaneously once a day for 5 d after viral-mediated transfection of GluR1(Q)flip into lumbar spinal cord motor neurons.