Fig. 4.

Effects of uptake inhibition by nomifensine on stimulated DA overflow in D₂−/− and WT mice.a, Examples of evoked DA overflow in slices from WT and D₂−/− mice before (solid lines) and after (dashed lines) a 20 min superfusion with 5 μm nomifensine. b, Increase in peak DA overflow over time in slices superfused with 5 μmnomifensine, normalized to overflow recorded in control medium (mean ± SEM; asterisks denote statistical difference from WT with p < 0.01), in WT mice (▵, n = 5), and D₂−/− mice (●,n = 7). c, The data shown inb are plotted as absolute values of peak DA overflow. Peak DA overflow in D₂−/− mice was smaller in control medium but reached the same level as DA overflow in WT mice after a 10 min superfusion with 5 μm nomifensine.