Fig. 9.

Voltage-gated peak currents evoked from oocytes expressing Kv1.4 subunits with the inserted Src family SH3 domain ligand sequence (Kv1.4-N-Pro and Kv1.4-C-Pro) are suppressed by Src family protein tyrosine kinase via a tyrosine phosphorylation-independent mechanism, whereas Kv1.4-wt is not modulated. The bars depict normalized mean ± SEM peak currents for each oocyte that was recorded after reinjection with kinase cRNA.p < 0.001 for overall effect by ANOVA (n > 11 oocytes for each experimental condition). Paired comparisons were performed with Bonferroni's multiple comparison test with experiment-wise p < 0.05. Significant differences for Kv1.4-wt: none; significant differences for Kv1.4-N-Pro: d versus e, dversus f, e versus g,f versus g; significant differences for Kv1.4-C-Pro: h versus i, hversus j, i versus k,j versus k.