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Increased binding of 1 μm[3H]GABA after receptor desensitization.A, Application of 500 μm GABA for 150 sec desensitized the GABA receptors. B, Specific binding of 1 μm [3H]GABA was determined in an oocyte, and then the oocyte was incubated in 500 μm GABA for 150 sec and rinsed for 30 sec, and the specific binding of 1 μm [3H]GABA was determined again in the same oocyte. Desensitization increased the specific binding from 163 ± 25 to 1253 ± 309 cpm (n = 8), a 7.7-fold increase.
