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. 2002 Sep 15;22(18):8133–8138. doi: 10.1523/JNEUROSCI.22-18-08133.2002

Fig. 5.

Fig. 5.

Effect of ΔFosB overexpression on wheel running behavior in bitransgenic mice. A, Bitransgenic mice drinking tap water have inducible overexpression of ΔFosB in striatal dynorphin neurons (water) and showed increased running (distance per day) for the first 3 weeks of access to running wheels. In contrast, genetically identical littermate controls with doxycycline in their drinking water that do not overexpress ΔFosB (dox) showed increased running for the first 2 weeks only. B, Another line of the bitransgenic strain of mice, called 11B, with inducible overexpression of ΔFosB primarily in striatal enkephalin neurons (water) showed dramatically less running during their weeks 2 and 3 compared with genetically identical littermates that do not overexpress ΔFosB (dox). # indicates an increase in running (distance per week) within a group. * indicates a difference in running between the ΔFosBoverexpressers (water) and controls (dox). Vertical lines indicate borders between weeks 1 and 2, as well as weeks 2 and 3. Horizontal lines with the # symbol describe statistical differences between weekly running within a group. Data are expressed as mean (11A dox,n = 8; 11A water, n = 7; 11B dox, n = 6; 11B water, n = 7).#p < 0.05;##p < 0.01;###p < 0.001; *p< 0.05.