Fig. 5.
Effect of intra-accumbens administration of non-opioid receptor antagonists on NSIA in morphine pre-treated and naïve rats. a, NSIA was blocked by either flupentixol (nonselective dopamine receptor antagonist) or SCH-23390 (selective D1-receptor antagonist) in morphine pretreated rats. b, NSIA was blocked by intra-accumbens administration, but not by offsite administration, of the nicotinic receptor antagonist mecamylamine in morphine pretreated rats. c, NSIA was blocked by SCH-23390 in naïve rats. SCH-23390 had no effect when administered alone. cap, Capsaicin. Group numbers, preceding group names, refer to the Tukeypost hoc analyses in Table 1.