Table 1.

Electrophysiological properties of oocytes and muscle expressing mutant AChRs

Mutant	Study type
	Single-channel oocytes			Voltage-clamp mouse diaphragm
	τ11-a	τ2	γ1-b	τs(n)1-c	τ1	τ2	Area (n)1-d	Amplitude (n)1-e
Wild type	0.8 ± 0.2	ND1-f	76 ± 6	1.31 ± 0.2 (5)	ND	ND	6.8 ± 0.33 (18)	2.72 ± 0.56 (5)
δS262T	3.8 ± 0.7	ND	72 ± 1	2.6 ± 0.51 (4)*	1.52 ± 0.25	5.2 ± 3.25**	7.54 ± 0.83 (26)	2.5 ± 0.55 (4)
αC418W	0.5 ± 0.2	16 ± 3	82 ± 2	3.1 ± 0.69 (7)**	1.64 ± 0.26	9.57 ± 3.0**	11 ± 1.44 (17)*	2.18 ± 0.32 (7)
αL251T	2 ± 1	150 ± 13	81 ± 4	2.94 ± 0.89 (6)*	1.22 ± 0.65	12.4 ± 3.3**	8.43 ± 0.89 (17)	2.12 ± 0.51 (6)
ɛL269F	2.7 ± 3	39 ± 7	83 ± 1	10.1 ± 2.95 (8)**	0.72 ± 0.26	25.8 ± 4.1**	30.8 ± 3.8 (12)**	2.04 ± 0.25 (8)***

All values are mean ± SEM (Weisberg, 1985). *p < 0.01, **p < 0.001, ***p < 0.04.

^F1-aTime constants (milliseconds) derived from fitting of open duration histograms to mono- or bi-exponential equations (Gomez et al., 1996b, 1997; Tamamizu et al., 1999). n = 3-10 patches.

^F1-bSingle-channel conductance (picoSiemans).

^F1-cTime constant (millisecond) of miniature endplate current decays fitted to one τ_s or two (τ₁ and τ₂) exponents (n= number of animals, where 4-18 endplates were studied per animal).

^F1-dMean area under curve described by MEPC (amperes per second).

^F1-eAmplitude of MEPC (nA) (n = number of animals, where 4-18 endplates were studied per animal).

^F1-fND, No significant component detected.