Fig. 4.

TRPV4 mediates heat-evoked currents in HEK 293 cells. A, Representative whole-cell current traces (at −60 mV) from HEK 293 cells stably transformed with TRPV4 or control vector during the temperature ramp indicated at thebottom. B, Representative temperature-response profiles derived from cells stably transformed with TRPV4, TRPV1, or control vector. C, Representative current–voltage relations for heat-evoked responses in cells transformed with TRPV4 (b), TRPV1 (c), or control vector (a). Similar patterns were observed in four cells of each type.