Fig. 2.

Experimental paradigms designed to assess the consistency (A) and pharmacological sensitivity (B) to GABA antagonist BIC and/or GLY antagonist STY on AS-specific suppression of spontaneous spike activity. Paradigm 1 consisted of three SCs in which the animal shifted from W to AS, and when the animal subsequently awakened from AS (RW). AS-specific suppression of spontaneous spike activity, i.e., percentage of change in spike rate during AS versus W was compared in each SC. The magnitude of AS-specific suppression for 10 DSCT neurons was compared between three consecutive SCs (Table 1). Paradigm 2 was used to assess the magnitude of AS-specific suppression before (SC1-control), during (SC2-test), and after (SC3-recovery) from the microiontophoretic administration of BIC and/or STY (Table 2).