Table 3.
Effect of BIC and STY on AS-specific suppression of spontaneous and EAA-evoked spike activity of DSCT neurons
| Spontaneous | EAA-evoked | |||||
|---|---|---|---|---|---|---|
| W | AS | RW | W | AS | RW | |
| Control | 24.6 ± 3.0 | 19.4 ± 4.23-150 | 24.5 ± 3.5 | 9.2 ± 1.2 | 3.1 ± 2.03-150 | 8.9 ± 1.2 |
| % change | ↓21.3 ± 10.2% | ↓0.7 ± 6.5% | ↓66.4 ± 26.6% | ↓3.8 ± 10.6% | ||
| % of control | (100%) | (78.7%) | (99.3%) | (100%) | (33.6%) | (99.7%) |
| BIC | 28.9 ± 3.7 | 29.5 ± 4.4 | 33.2 ± 4.1 | 12.4 ± 1.9 | 13.3 ± 2.1 | 15.1 ± 2.9 |
| % change | ↑2.4 ± 7.9% | ↑15.1 ± 6.6% | ↑7.4 ± 7.4% | ↑22.4 ± 16.7% | ||
| % of control | (100%) | (102.4%) | (115.1%) | (100%) | (107.4%) | (122.4%) |
| STY | 28.9 ± 2.6 | 25.5 ± 2.2 | 30.7 ± 3.1 | 12.4 ± 1.9 | 13.7 ± 2.6 | 12.3 ± 1.5 |
| % change | ↓11.8 ± 3.9% | ↑6.2 ± 4.4% | ↑10.7 ± 13.1% | ↓0.7 ± 6.6% | ||
| % of control | (100%) | (88.2%) | (106.2%) | (100%) | (110.7%) | (99.3%) |
EAA responses were corrected for spontaneous activity (see Materials and Methods). Data from four cells excited by GLU (−90.7 ± 32.2 nA; 10 sec, 20 sec intervals) and three cells excited by AMPA (−70.7 ± 11.0 nA; 6 sec, 60 sec intervals) are combined and data expressed as in Tables 1 and 2. Downward arrows represent percentage of decrease, whereas upward arrows represent a percentage of increase in spike activity. BIC and STY were administered separately in each cell in separate test SCs. AS-specific suppression of spontaneous and EAA-evoked responses measured 21.3 and 66.4%, respectively (
F3-150: p < 0.05; ANOVA). After BIC (29.8 ± 10.4 nA; 15.7 ± 3.0 min), AS-specific suppression of these parameters was abolished. After STY (32.7 ± 18.4 nA; 18.6 ± 9.4 min), neither spontaneous activity nor EAA-evoked spike activity was suppressed during AS (p > 0.05; ANOVA).