Skip to main content
. 2002 Jul 1;22(13):5536–5551. doi: 10.1523/JNEUROSCI.22-13-05536.2002

Fig. 11.

Fig. 11.

Model of BDNF, NGF, and CNP actions in the olfactory system. 1, NGF is released from apoptotic cells within the regenerating olfactory epithelium and acts on basal cells to promote their division to form basal daughter cells that then migrate to a region slightly above the basal layer (2). 3, In the absence of other factors, these cells then undergo apoptosis. 4, BDNF is released from cells within the basal layer and acts on basal daughter cells to allow them to undergo further rapid proliferation (5). 6, In the absence of other factors, these cells become quiescent. 7, CNP can act at either the level of the basal cells or their daughter cells to inhibit growth factor-induced proliferation and promote cell differentiation to the next stage of maturation. CNP by itself has no effect. CNP appears to be released from mature cells within the olfactory epithelium at P1, and later by sustentacular cells in the adult animal. 8, CNP also promotes the survival of more mature, OMP-positive neurons within the olfactory epithelium, perhaps through its presence in the olfactory bulb. Within less mature animals (P1), CNP appears within the forming glomeruli and mitral cell layer, whereas in the adult it appears in the periglomerular cells surrounding each glomeruli and also in the mitral cell region.