Fig. 3.

Effects of SST on K⁺ currents were occluded by 0.1 mm Ba²⁺, 0.1 mm Cs⁺, and 10 nmtertiapin-Q. A1, Continuous current record of experiment showing reversible effects of local perfusion with control solution, 200 nm SST, and SST + 0.1 mmBa²⁺. Dashed line, Baseline holding current; vertical lines, responses to 100 msec voltage steps from −60 to −75 mV, applied at 1 Hz. A2,Left, Individual current responses in the four conditions of A1. SST elicited an outward shift of holding currents (SST), reversed by concurrent Ba²⁺ perfusion (SST + Ba²⁺). A2,Right, Current responses aligned to baseline level demonstrate changes in conductance under different conditions.B1, Currents elicited by voltage ramps (−130 to 0 mV, 1 sec) in 30 mm external K⁺ in an RT neuron. The increased conductance produced by SST was occluded by 0.1 mm Ba²⁺. B2, Summary of effects of various ion channel blockers on SST-evoked currents in RT neurons. *p < 0.05, **p < 0.01 vs SST alone (n = 5–12 for each treatment).C1, Continuous current record of experiment showing occlusion of SST effects by 0.1 mmBa²⁺. Dashed line, Baseline holding current; vertical lines, responses to 100 msec voltage steps from −60 to −80 mV, applied at 1 Hz. C2, Summary of Ba²⁺ pre-perfusion on SST-evoked currents in RT neurons. *p < 0.05 (n = 4).