Fig. 7.

Characteristics of IPSCs recorded from CA1 pyramidal neurons in hippocampal slices in vitroprepared from WT and α5 −/− mice. a, Examples of recordings of membrane current from CA1 neurons in WT and α5 −/− mice at a holding potential of −60 mV. The regular downward deflections are sIPSCs. b, Cumulative frequency distributions of the sIPSC amplitude and interevent interval in WT (black;n = 15 slices) and α5 −/− mice (red;n = 13 slices), showing a clear reduction in IPSC amplitude but no change in IPSC frequency in the α5 −/− mice. c, Representative sIPSCs recorded from CA1 pyramidal neurons in hippocampal brain slices from WT and α5 −/− mice. In the examples shown, the decay of the sIPSC recorded from the WT mouse was best fitted to a double-exponential function, whereas the decay of the sIPSC recorded from the α5 −/− mouse was best fitted to a monoexponential function (decay fits superimposed in red).d, Summary of the mean data of spontaneous and evoked IPSC mean peak amplitude and decay kinetics from WT and α5 −/− mice.