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[3H]MK-801 binding in forebrain synaptic membranes of adult GluRε4 mutant mice. Triton X-100-treated forebrain synaptic membranes were incubated with 5 nm [3H]MK-801 at 30°C for 16 hr, in the presence or absence of 10 μm glutamate (Glu), Glu plus 10 μm glycine (Gly), or Glu plus Gly plus 1 mm spermidine (SPD). Each column represents the mean ± SEM (n = 6). *p < 0.05 and **p < 0.01 versus wild-type (+/+).
