Fig. 7.
Rebound can be completely blocked by a combination of IH and INaantagonists. Membrane potential traces are plotted versus time under three different conditions in a single neuron. After eliminating theIH component with 100 μmZD7288, PRF in this neuron was reduced from 63 (left trace) to 27 spikes/sec (center trace). Addition of the Na channel blocker TTX eliminated all postinhibitory rebound depolarization (right trace), indicating that either spiking or a TTX-sensitive Na+ current is necessary for the IH-insensitive component of PRF. Dashed line indicates −60 mV.