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. 2002 Mar 15;22(6):2083–2095. doi: 10.1523/JNEUROSCI.22-06-02083.2002

Fig. 9.

Fig. 9.

Firing dynamics of an integrate-and-fire model with rebound and adaptation currents. A1–A3, Firing responses in an MVN neuron with strong PRF (70 spikes/sec;left) and in a modeled neuron (right). Responses to depolarizing steps (A1), hyperpolarizing steps (A2), and sinusoidal current injection at 0.5 Hz (A3) are shown. The simulated adaptation and rebound conductances were adjusted until the model reproduced the data. The model was then tested with sinusoidal current injection without further adjustments of parameters. The response phase of the model (12.1°) closely reproduced the experimental result (11.7°).B1–B3, As in A1–A3, but for a neuron with weak PRF (10 spikes/sec). Weak FRA (B1) and weak PRF (B2) were modeled by reducing the respective conductances by about an order of magnitude with respect to those in neuron A. The modeled response phase was 0.9°, and the experimental result was 0.4°. C, Comparison of phase versus frequency in real and modeled neurons. D, Comparison of results from model neuron A with all conductances (full model), with the PRF conductance set to 0 (without PRF), and with the FRA conductance set to zero (without FRA). The FRA conductance produces a phase lead, whereas the PRF conductance has little effect on phase.