Fig. 12.

Diagram of the putative itinerary of endosomal compartments in distal dendrites. Clathrin-coated pits invaginate to form coated vesicles that become large vesicles after the loss of the coat. Large vesicles merge into tubular endosomes and MVB–tubular complexes. Sorted, soma-bound material leaves the dendrite via isolated MVBs. The coated tips of tubular endosomes give rise to small, round vesicles that return to fuse with the plasmalemma. The source and target regions of the plasmalemma for these components are likely to be disparate.