Fig. 4.

Amyloid load in the anterior cortex and hippocampus of NCX-2216-treated mice. Amyloid load is the percentage of the cross-sectional area occupied by Congo red stain. NCX-2216-treated APP+PS1 mice have significantly less amyloid in both the cortex (A) and hippocampus (B), as demonstrated by Congo red staining, compared with mice treated with ibuprofen (cortex, p < 0.002; hippocampus,p < 0.005), celecoxib (cortex,p < 0.02; hippocampus, p < 0.02), or fed the control diet (cortex, p < 0.001; hippocampus, p < 0.01).