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Locomotor activity (horizontal activity, total distance traveled, vertical activity, center distance) in rats with neonatal TTX infusions. Motor activity was recorded in response to MK-801 (0.1 and 0.2 mg/kg, s.c.) 11 weeks after TTX infusion. TTX rats that were administered 0.2 mg/kg MK-801 showed exaggerated motor hyperactivity compared with sham controls (*p < 0.05; n = 5–8 per group).
