Fig. 7.

Oral consumption of cocaine, morphine, sucrose, and quinine in a two-bottle choice paradigm in WT and α1b-AR KO mice. Consumption of water, cocaine (0.2 mg/ml), morphine (0.15 mg/ml), and different concentrations of sucrose and quinine were measured in a two-bottle choice paradigm, as described in Materials and Methods, and were expressed in percentage of total fluid intake.N = 7–9 animals per group. *p< 0.05, **p < 0.01 when cocaine or morphine consumption significantly differed from water consumption (paired Student's t test). °p < 0.05, °°°p < 0.001 when consumption of α1b-AR KO mice significantly differed from consumption of WT mice (unpaired Student's t test).