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. 2002 Apr 1;22(7):2753–2763. doi: 10.1523/JNEUROSCI.22-07-02753.2002

Fig. 3.

Fig. 3.

X-Gal staining of telencephalon or brains ofFmr2 knock-out mice. A, X-Gal staining of telencephalon of embryonic day 10.5. The ganglionic hillock is labeled.B, X-Gal staining of telencephalon of embryonic day 12.5. The wall of cerebra was divided into three zones: matrix zone at the ventricular lumen, intermediate zone, and marginal zone. The neuroblasts for the cerebral cortex migrate out of the inner matrix zone, where critical mitosis occurs, and enter the marginal zone, where they form the cortical plate. The neuroblasts in the cortical plate are no longer able to divide. C, X-Gal staining of cerebra (frontal cortex) at embryonic day 15. The neuroblasts and neuronal cells have not reached the outer one-third zone of cerebral cortex when neuroblasts migrate from inside matrix zone to outside zone, passing the neurons differentiated by neuroblasts migrating out early.D, X-Gal staining of the adult cerebellum. The most highly stained cells are Purkinje cells. E, X-Gal staining of adult brain, cut by coronal section. CA1, CA3, and dentate gyrus of hippocampus are strongly stained by X-Gal. The amygdala is also well stained. F, Enlargement of X-Gal staining of the hippocampus from D. G, Hematoxylin and eosin staining of adult brain by coronal section. No abnormalities are observed. H, Hematoxylin and eosin staining of adult cerebellum. These structures appear normal. GE, Ganglionic eminence; MZ, matrix zone; PP, preplate; IZ, intermediate zone; MaZ, marginal zone; CP, cortical plate; PC,Purkinje cell layer of cerebellum; AM, amygdala;DG, dentate gyrus of hippocampus.

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