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Reductions in striatal DA and DOPAC and TH activity levels over time. A, B, Striatal DA content (A) and TH activity (B) were reduced by ∼40–50% at all time points; C, striatal DA turnover, as assessed by the DOPAC/DA ratio, was increased by ∼60% at all time points in the α-synuclein transduced animals (filled circles) but only transiently increased in the GFP group (open circles). † p < 0.05 (effect of group, two-way repeated measures ANOVA).
