Fig. 7.

Changes in motor behavior. In all three tests the overall performance of the α-synuclein transduced animals did not differ from the GFP group (p > 0.05 for all contrasts). However, in both the apomorphine rotation test (A; data from the 8 week test) and the paw reaching test (B; performed at 24 weeks) 25% of the α-synuclein transduced animals were clearly impaired in that they scored lower than any animal in the GFP control group (filled circles). Bars in A and B give means ± 1 SD. C, A single low dose of the DA synthesis inhibitor α-methyl-dl-p-tyrosine, given on the fourth day of testing, produced a significant impairment in the stepping test. † Different from both predrug test and GFP group atp < 0.0125.