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. 2002 Apr 1;22(7):2916–2925. doi: 10.1523/JNEUROSCI.22-07-02916.2002

Fig. 2.

Fig. 2.

Reinstatement of drug seeking by administration of cocaine into the mPFC and nucleus accumbens, but not the neostriatum or lateral septum. The data summarized in this figure depict the response rate (Lever presses/Min) during the fifth component of the FI10(FR10) second-order schedule of reinforcement for the last self-administration (SA) and extinction (Ext) sessions as well as during the reinstatement phases of these experiments. These data indicate that microinjection of 100 μg cocaine directly into the mPFC (A) or nucleus accumbens (B) but not into the neostriatum or lateral septum (C and D, respectively) reinstates drug-seeking behavior. The error bars indicate ±SEM. The asterisks represent significant differences from the vehicle control (p < 0.05; Tukey's HSD). There were 5–10 rats per treatment.