Table 1.
Ki values for muscarine at four pulse amplitudes at different experimental conditions
| Depolarizing pulse amplitude | Ki values (μm) | ||
|---|---|---|---|
| Control (n = 6) | PTX-treated (n = 6) | B-oligomer-treated (n = 4) | |
| −0.6 μA | 0.23 ± 0.03 | 31.0 ± 2.6 | 0.19 ± 0.05 |
| 1-165 | * | 1-165 | |
| −0.9 μA | 0.95 ± 0.1 | 31.8 ± 4.3 | 0.92 ± 0.1 |
| 1-165 | * | 1-165 | |
| −1.2 μA | 3.5 ± 0.4 | 32.5 ± 4.2 | 3.8 ± 0.4 |
| 1-160 | * | 1-160 | |
| −1.5 μA | 8.0 ± 0.9 | 33.1 ± 3.1 | 8.1 ± 0.9 |
Ki values obtained at two depolarization levels were compared by unpaired one-tailed t test. The significance for difference between Ki values for each column for two successive pulse amplitudes is given:
insignificant difference (p > 0.4);
F1-160: significant difference (p < 0.05);
F1-165: highly significant difference (p < 0.001). The difference for the minimal and the maximal pulse amplitudes in both the control and in B-oligomer-treated preparations was highly significant (p < 0.0001). The difference between control and PTX-treated preparations was highly significant (p < 0.0001) for each pulse amplitude. The difference between controls and B-oligomer-treated preparations was insignificant (p > 0.5) for each pulse amplitude.