Fig. 4.
Inhibition of CRF receptors, PKC, and CaMKII in the dorsal hippocampus prevents stress-mediated enhancement of context-dependent fear conditioning. A, Mice were injected intrahippocampally (i.h.) or intracerebroventricularly (i.c.v.) with aCSF, KN-62, or BIS-I immediately before the start of the stress session and trained at several time points after the end of the stress session.B, Mice were injected intrahippocampally or intracerebroventricularly with [Glu11,16]astressin immediately before the stress session and trained 2 hr after immobilization. Freezing was measured in the memory test performed 24 hr after training. Statistically significant differences: *p < 0.05 versus aCSF; **p < 0.05 versus control.