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. 2002 May 1;22(9):3359–3365. doi: 10.1523/JNEUROSCI.22-09-03359.2002

Fig. 4.

Fig. 4.

PI3-kinase is required for the expression of both NMDA- and VDCC-dependent forms of CA1 LTP.A, L-type VDCC-dependent form of LTP of fEPSP was induced at Schaffer collateral/commissural fiber–CA1 synapses in the presence of d-AP-5 (50 μm). A 20 min application of LY294002 (100 μm) 30 min after the induction of VDCC-dependent LTP abated LTP in the tetanized pathway (n = 6) (black squares), but no change was seen in the fEPSP in the untetanized pathway (white circles). B, Inhibition of PI3-kinase with LY294002 (100 μm) also abated NMDA-dependent LTP induced in the presence of nifedipine (30 μm).