Fig. 3.

Systemic DOC administration elevates clonic seizure threshold and plasma THDOC levels. Rats were injected intraperitoneally with vehicle (control) or various doses of DOC. Thirty minutes later, the seizure threshold was estimated by intravenous infusion of PTZ. Immediately after seizure occurrence, plasma samples were collected for THDOC determination by liquid chromatography–mass spectrometry. Data represent mean ± SEM (n = 7–8 per group). *p < 0.05 versus control; **p < 0.01 versus control (Dunnett's t test). Plasma THDOC values are all significantly different from control (p < 0.001).