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. 2002 May 1;22(9):3795–3805. doi: 10.1523/JNEUROSCI.22-09-03795.2002

Fig. 4.

Fig. 4.

Protective activity of DOC in the PTZ seizure test correlates with plasma THDOC levels. DOC (25–200 mg/kg, i.p.) was administered to male mice 30 min before injection of PTZ (85 mg/kg, s.c.) or plasma collection. Each point in the seizure test curve represents eight mice; each point in the plasma THDOC curve represents the mean ± SEM of THDOC determinations in a separate group of six mice. There is a high correlation (r = 0.91;p < 0.001) between the dose–response relationship for seizure protection and the mean plasma THDOC levels.