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. 2002 May 1;22(9):3795–3805. doi: 10.1523/JNEUROSCI.22-09-03795.2002

Fig. 5.

Fig. 5.

Finasteride and indomethacin inhibit the protective activity of DOC in the PTZ seizure test. A, Dose–response relationship for DOC (50–300 mg/kg, i.p.) protection against PTZ seizures is shifted to the right by pretreatment with finasteride (10 mg/kg, i.p.) or indomethacin (100 mg/kg, i.p.).B, Dose–response relationship for finasteride (1–50 mg/kg, i.p.) or indomethacin (10–300 mg/kg, i.p.) inhibition of the anticonvulsant activity of DOC (168 mg/kg) in the PTZ test.A and B, Finasteride or indomethacin was administered 60 or 30 min, respectively, before the DOC injection. Each point represents data from eight mice.