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. 2002 May 1;22(9):3795–3805. doi: 10.1523/JNEUROSCI.22-09-03795.2002

Fig. 6.

Fig. 6.

Anticonvulsant activity of DHDOC and THDOC in the PTZ seizure test: effects of finasteride (Finast.) and indomethacin (Indomet.). A, Dose–response relationships for protection by DOC, DHDOC, and THDOC in the PTZ seizure test. B, Time courses for protection against PTZ-induced seizures by DOC (168 mg/kg, i.p.), DHDOC (52 mg/kg, i.p.), and THDOC (38 mg/kg, i.p.) administered at time 0. Thepoints at time 0 represent the simultaneous administration of PTZ and a neurosteroid. The linesrepresent arbitrary fits to the data points. C, Dose–response relationship for DHDOC protection against PTZ seizures is shifted to the right by indomethacin (100 mg/kg, i.p.) pretreatment but not by finasteride (10 mg/kg, i.p.) pretreatment. D, Lack of effect of finasteride and indomethacin pretreatment on the dose–response relationship for THDOC protection against PTZ seizures. Finasteride or indomethacin was administered 60 or 30 min, respectively, before the DHDOC or THDOC injections. Each point represents data from eight mice.