Fig. 10.

Neuronal cell bodies were not lost in the hippocampal CA1 subfield at 12 months in Tg2576/PS1^P264L. Cell counts were performed in littermate brains after cresyl violet staining of Tg2576/PS1^P264L, PS1^P264L, or wild-type frozen sections. Animals were either 2 or 12 months of age. A 17% reduction in CA1 neuronal number present at 12 months in Tg2576/PS1^P264L CA1 was also present at 12 months in PS1^P264L mice and at 2 months in Tg2576/PS1^P264L mice. These data indicate that any reduction is not attributable to age/amyloid burden but may be developmental and attributable to the PS1^P264Lmutation. Five subjects in each group, except for the PS1^P264L group with three subjects.