Fig. 6.

Activated JNK within amyloid deposits is localized to neurites containing phospho-tau. Tg2576/PS1^P264L cortex at 12 months, stained with an antibody to phospho-thr231 tau (A, D) phospho-JNK (B, E), or phospho-ser202 tau (C, F). A–C andD–F constitute serial sections through two separate amyloid deposits. Arrows indicate some of the neurites that overlap between two serial sections; arrowheadsindicate neurites that overlap between all three sections. Scale bars: (in A) A–C, 15 μm; (inD) D–F, 12 μm.