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Age-dependent activation of p38 in the Tg2576/PS1P264L cortex. A, Thetop demonstrates 100 μg of cortical protein, stained with an antibody selective for activated p38 phosphorylated by an upstream kinase such as MKK3/6. The bottom depicts total p38 protein, which is relatively constant with age. Bdepicts the active fraction of p38 that increases with age and amyloid burden. Six samples per group were each assayed in triplicate on immunoblot. *p ≤ 0.05 indicates significant differences.
