Fig. 3.
Blockade of endogenously activated 5-HT2A receptors reduces action potential discharge in inspiratory neurons. A–B, Toppanels, Intracellular recording from two inspiratory neurons at a slow time scale. Population activity is not shown.Bottom panels, Intracellular recordings from the same inspiratory neurons before (left) and after (right) the application of piperidine. Intracellular recordings are shown at a faster time scale together with the simultaneously recorded integrated population activity (top traces). Arrows show approximately the time at which the bottom traces were taken. Note the reduction in the amplitude of the spontaneous action potentials during the interburst interval (which is dramatic in the neurons shown inA) and during the population burst (for comparison, see the line).