Table 1.
Drug-seeking behavior during reinstatement tests and after various doses of lidocaine
| rBLA | Cue-induced reinstatementa | Prime + cue-induced reinstatementb | ||||||
|---|---|---|---|---|---|---|---|---|
| Cues | S− | S+ | S+ | S+ | S+ | S+ | S+ | S+ |
| Condition/dose (μg) | 0 | 0 | 10 | 0 | 10 | 30 | 56 | 100 |
| 0–15 | 20 (16) | 76 (39) | 2 (1) | 44 (25) | 48 (22) | 32 (25) | 15 (10) | 11 (5) |
| 15–30 | 4 (4) | 20 (3) | 3 (2) | 42 (25) | 51 (27) | 40 (14) | 23 (12) | 9 (3) |
| 30–45 | 2 (1) | 12 (4) | .2 (.2) | 66 (22) | 57 (39) | 28 (8) | 30 (5) | 15 (3) |
| 45–60 | .4 (.4) | 22 (10) | 2 (1) | 61 (25) | 30 (19) | 41 (7) | 19 (9) | 18 (6) |
| cBLA | Cue-induced reinstatementc | Prime + cue-induced reinstatementd | ||||||
| Cues | S− | S+ | S+ | S+ | S+ | S+ | S+ | S+ |
| Condition/dose (μg) | 0 | 0 | 10 | 0 | 10 | 30 | 56 | 100 |
| 0–15 | 1 (.6) | 24 (12) | 50 (24) | 19 (12) | 38 (27) | 15 (9) | 21 (17) | 11 (6) |
| 15–30 | 0 (0) | 7 (3) | 37 (16) | 11 (8) | 31 (17) | 30 (19) | 12 (9) | 24 (12) |
| 30–45 | 3 (3) | 15 (8) | 23 (7) | 37 (9) | 33 (9) | 31 (20) | 12 (6) | 11 (4) |
| 45–60 | 3 (2) | 24 (9) | 37 (21) | 82 (44) | 31 (19) | 7 (3) | 10 (5) | 16 (4) |
| ANOVA analyses: | |||
| Conditiona | F(2,10)= 6.6; p ≤ 0.02 | Doseb | F(4,20) = 4.7; p ≤ 0.01 |
| Time | F(3,15) = 2.2; p ≤ 0.13 | Time | F(3,15) = 2.2; p ≤ 0.13 |
| Condition × time | F(6,30) = 2.3;p ≤ 0.10 | Dose × time | F(12,60) = 0.8; p ≤ 0.63 |
| Conditionc | F(2,8)= 5.9; p ≤ 0.03 | Dosed | F(4,16) = 3.9; p ≤ 0.02 |
| Time | F(3,12) = 0.8; p ≤ 0.52 | Time | F(3,12) = 0.7;p ≤ 0.60 |
| Condition × time | F(6,24) = 0.6; p ≤ 0.68 | Dose × time | F(12,48) = 2.8;p ≤ 0.01 |
Values are the mean (SEM) responses for successive 15 min periods during 1 hr test sessions.
a,bANOVA analyses in rBLA implanted rats.
c,dANOVA analyses in cBLA implanted rats.